Glutamine Synthetase (Gl Syn) forms a homo octamer that is a catalyst for the amination of glutamic acid to glutamine. It is a marker for astrocytes that serve as the primary site of conversion of glutamic acid to glutamine in the brain. Elevated level expression of glutamine Synthetase in glial cells has shown to protect neurons from degeneration due to excess glutamate. Glutamine Synthetase is present in the Testis and is involved in nitrogen homeostasis. Over expression of glutamine Synthetase was seen in Testis cancers.
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