GATA-3 (GATA binding protein 3) belongs to the family of transcription factor, which bind directly to the nucleotide sequence core element to control diverse tissue-specific programs of gene expression and morphogenesis. Its expression is seen in hematopoietic and non-hematopoietic tissues/cells such as mammary glands and T cells. GATA-3 functions as a major regulator of T helper 2 cell (Th2) differentiation in immune cells and differentiation of luminal epithelial cells in mammary glands. GATA-3 has also been a novel marker for bladder cancer and also expression is seen in 67% of 308 urothelial carcinomas but no prostate or renal carcinomas.
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