DatasheetSDS

Galectin 3 also designated as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, belongs to galectin family which are soluble b galactoside-binding animal lectins. They modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apoptosis. Galcetin-3 is a chimera galectin that has a tendency to dimerize. It promotes cell growth and proliferation for many cell types. Galectin-3 acts intracellularly to prevent apoptosis. It exhibits pro- or anti-adhesive properties on different type of cells. Galectin-3 chemoattracts monocytes and macrophages. It activates and degranulates basophils and mast cells. Galectin-3 is expressed in tumor cells, osteoclasts, epithelial cells, fibroblasts, colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. It binds various matrix glycoproteins including laminin, fibronectin, LAMPS, 90K/Mac-2BP, MP20, and CEA. Elevated circulating levels of Galectin-3 have been show to correlate with the malignant potential of several types of cancer, suggesting that Galectin-3 is also involved in tumor growth and metastasis.