DatasheetSDS

Filaggrin protein is an intermediate filament-associated protein that aggregates keratin intermediate filaments in epidermis. It is initially synthesized as a polyprotein precursor molecule, profilaggrin (a large, insoluble, highly phosphorylated precursor protein containing several tandem copies of a 324 amino acid). Profilaggrin is proteolytically processed into active filaggrin molecules and these molecules promote aggregation by forming disulfide-bond of keratin intermediate filaments during terminal differentiation of the epidermis. Filaggrin expression is seen only in well differentiated keratinized epithelial cells. Mutations in this gene are associated with ichthyosis vulgaris with viral, premalignant and malignant conditions.