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Anti-Ferritin Light chain

SKU: AM935GP Categories: , ,
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Product Description

Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed in serum and tissues, and oxidative stress, an important factor in the development of ageing-related cataracts.

Intended Use

RUO

Antibody Type

Monoclonal

Clone

FTL/1389

Source

Mouse

Tissue Type/Cancer Type

Lung Cancer, Tonsil

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual