Anti-Factor XIIIa, Clone AC-1A1


Factor XIII is a zymogen which is converted into its active form, Factor XIII, by Thrombin. Factor XIII has potentially 2 catalytically active subunits (Factor XIIIa) and 2 inhibitory subunits (Factor XIIIb). Factor XIIIa is a pro transglutaminase that belongs to a family of transglutaminases. It catalyzes the formation of covalent cross-links in fibrin. Without Factor XIIIa, a pro transglutaminase that belongs to a family of transglutaminases, fibrin is instable and physiologically inadequate. Factor XIIIa consists of 732 amino acids and a molecular mass of 83 kDa. Factor XIIIa is primarily in cells of bone marrow origin. It is present in platelets in large quantities. It is about 3% of total protein content of platelets. Factor 13a is also detected in monocytes. Factor XIII is an important part of the clotting cascade, and its activation is required during the final phase of the clotting cascade when it is activated by thrombin and Ca2+ ions. Fibrin is prominent substrate for Factor XIIIa. Factor XIIIa is a useful marker in differentiating dermatofibroma and dermatofibrosarcoma protuberans, as it is mostly expressed in dermatofibroma.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: AC-1A1
Source: Mouse
Tissue Type/Cancer Type: Placenta tissue

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