The determination of steroid hormone receptors has become widely used in the management of hormone-dependent cancers. The Estrogen Receptor content of breast carcinoma is a tool for both prognosis and response to endocrine therapy. Individuals whose tumors contain estrogen receptor are more likely to respond to endocrine manipulation than those whose tumors are estrogen receptor poor. Estrogen Receptor (ER) modulates cellular events by binding estrogen response elements (ERE) when bound to estrogen in dimers. This results in the transcription of a number of proteins, including ER. Protein synthesis occurs in the cytoplasm, after which ER associates with chaperone proteins and is translocated to the nuclear membrane. The ER protein is transported into the nucleus through utilization of ATP.
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0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual