EGFR (Epidermal growth factor receptor) also known as HER1 or ErbB1, is a 170 kDa integral transmembrane tyrosine kinase glycoprotein belongs to HER/ERbB protein family. EGFR binding to its ligands (EGF, TGFα, Amphiregulin and HB-EGF) results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation. Overexpression of EGFR is observed in tumors of the head and neck, stomach brain, bladder, breast, endometrium, esophagus, cervix, lung vulva, ovary, stomach and in squamous cell carcinoma.
|Tissue Type/Cancer Type||
Transitional Cell Carcinoma Tissue
6 mL – Manual – RTU, 100 Tests – Automation – i6000, 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP®, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual