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Anti-EGFR
SKU: AMC68GP Categories: , ,

EGFR (Epidermal growth factor receptor) also known as HER1 or ErbB1, is a 170 kDa integral transmembrane tyrosine kinase glycoprotein belongs to HER/ERbB protein family. EGFR binding to its ligands (EGF, TGFα, Amphiregulin and HB-EGF) results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation. Overexpression of EGFR is observed in tumors of the head and neck, stomach brain, bladder, breast, endometrium, esophagus, cervix, lung vulva, ovary, stomach and in squamous cell carcinoma.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

GFR/2596

Source

Mouse

Tissue Type/Cancer Type

Transitional Cell Carcinoma Tissue

Pack

6 mL – Manual – RTU, 100 Tests – Automation – i6000, 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP®, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual