DatasheetSDS

EBV antibody is a mixture of four different monoclonal antibodies. All three antibodies in this combination recognize distinct epitopes in the hydrophilic carboxyl region of the latent membrane protein (LMP) protein encoded by the Epstein Barr Virus antibody (EBV). This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. EBV has been implicated with Hodgkin?s disease, and may be involved in the pathogenesis of Hodgkin?s occurring in children. Other studies have shown a low incidence of EBV in B-cell type lymphomas unless patients were immunologically impaired, such as postorgan transplantation or autoimmune type diseases. Studies have shown that this antibody does stain EBV + Burkitt?s lymphomas but has shown some cross reactivity with smooth muscle and blood vessels.