E-Cadherin is a glycoprotein transmembrane with an important role in epithelial cell adhesion. E-Cadherin may act as a suppressor of invasion in neoplastic progression. The expression of E-Cadherin is reported to be absent or reduced in prostate cancers for example, in comparision with its expression in normal prostate which is uniformly strong. A decreased expression of E-Cadherin is associated with metastatic potential and poor prognosis in breast cancer and esophagus cancer. In combination with p120 Catenin or Cytokeratin it is useful for the differentiation between ductal (E-Cadherin positive) and lobular (E-Cadherin negative) breast carcinomas. It may also help in diagnosis of mesothelioma
Intended Use: IVD
Antibody Type: Monoclonal
Clone: EP6
Source: Rabbit
Tissue Type/Cancer Type: Breast Ca