DatasheetSDS

Desmoglein 3 (Dsg3), also known as Cadherin family member 6(CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. DSGs/ desmocollin (DSCs) are anchored to the intracellular plaque proteins plakoglobin, plakophilins, and desmoplakin, the latter of which mediates connection to the intermediate filament cytoskeleton. Desmoglein 3 is predominately expressed in stratified squamous epithelia including epidermis, tongue, tonsil, esophagus and carcinomas. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris wherein the binding of anti-desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis. The Desmoglein 3 antibody has been cited as a superior marker for Lung Squamous Cell Carcinomas, and helps distinguish lung squamous cell carcinoma cases from lung adenocarcinomas. Studies have also shown that a panel consisting of Desmoglein-3 utilized with Napsin A can be a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinomas from other subtypes. Lung cases that are typically positive for Desmoglein 3 tend to have a poor clinical outcome.