The two keratins specifically type II keratin CK5 and type II CK6, which essentially form 8-nm filaments. CK5 is a useful immunohistochemical marker in different studies of mesothelioma, and the expression is key tool for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin. CK5 labels myoepithelial cells of breast and prostate basal cells. The human type II Cytokeratin 6 (CK6) a 56 kD protein expressed on stratified epithelia including oral mucosa, esophagus, basal layer of epidermis, the outer root sheath of hair follicles, and in glandular epithelia. CK6 paired with CK5 is useful to differentiate mesothelioma (positive) from lung carcinoma (negative) or metastatic carcinoma (negative) in the pleura. In psoriasis, CK6 is a marker of hyper proliferative and activated keratinocytes. CK5/6 has also been used to distinguish usual ductal hyperplasia of the breast (strong staining) from solid papillary DCIS (negative).
EP24 & EP67
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual