DatasheetSDS

Cytokeratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one acidic type I cytokeratin (cytokeratins 9 to 23) and one type neutrol-basic II cytokeratin (cytokeratins 1 to 8). Cytoikeratins 7 and 8 are two closely related type II cytokeratins characteristic of simple epithelia. Cytokeratin 7 is less widespread than cytokeratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Cytokeratin 8 is primarily found in the non squamous epithelia. Cytokeratin 7 is usually present in adenocarcinomas of lung, breast, endometrioid tumors, and transitional cell carcinoma of the bladder. Combination of cytokeratin 7 and 8 is a useful maker for differentiating adenocarcinomas and ductal carcinomas from squamouse cell carcinomas.