Cytokeratin 4 (CK4) is a 59kDa intermediate filament protein associated with cytokeratin 13. It is expressed in suprabasal cells of non-keratinized stratified squamous epithelium of esophagus, cornea, anus, pharynx and tongue. A mutation in CK4 gene causes white sponge nevus. A decreased expression of CK4 is associated with head and neck squamous carcinoma. Antibody to CK4 is helpful in differentiation of squamous cell carcinoma of esophagus origin from thyroid origin.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual