Anti-Cytokeratin 4


Cytokeratin 4 (CK4) is a 59kDa intermediate filament protein associated with cytokeratin 13. It is expressed in suprabasal cells of non-keratinized stratified squamous epithelium of esophagus, cornea, anus, pharynx and tongue. A mutation in CK4 gene causes white sponge nevus. A decreased expression of CK4 is associated with head and neck squamous carcinoma. Antibody to CK4 is helpful in differentiation of squamous cell carcinoma of esophagus origin from thyroid origin.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: EP4
Source: Rabbit
Tissue Type/Cancer Type: Esophagus