This monoclonal antibody recognizes an intermediate filament protein of 46 kDa, identified as cytokeratin 20 (KRT20, CK20). CK20 is abundantly expressed in goblet cells and enterocytes of the gastrointestinal tract. It plays a significant role in maintaining keratin filament organization in intestinal epithelia. It is a useful marker of pancreatic and colorectal cancer and has been detected in adenocarcinomas of the colon, stomach, and biliary tract. Diseases associated with CK20 include Merkel cell carcinoma and glandular cystitis. Breast carcinomas are generally non-reactive.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | KRT20/1992 |
| Source | Mouse |
| Tissue Type/Cancer Type | Colon tissue |
| Pack | 6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 160 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual |
