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Cytokeratin 15 (CK15) plays a key role in the development of stratified epithelia from one-layered polar epithelia and continues to be expressed in several adult epithelial tissues. ?Cytokeratin 15 labels the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. CK15 is absent from hair bulbs in normal hair follicles, it was expressed by a subset of keratinocytes in the outer root sheath. In human conjunctival epithelium, strong expression of CK15 was observed in basal cells, whereas Cytokeratin 19 was expressed in both basal and suprabasal layers. CK15 may be used to differentiate primary from metastatic skin cancer. It may be a useful stem cell marker for hair follicle and breast epithelium