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Cytokeratin 13 is a part of the keratin gene family, more specifically a type 1 keratin, as non-keratinized squamous epithelial marker. Type 1 keratins, compared to type 2 keratins, tend to be smaller and more acidic. These keratins constitute the type intermediate filaments of the intracytoplasmic cytoskeleton that are responsible for the structural integrity of mammalian epithelial cells. Cytokeratin 13 has been found to play a directive role in prostate cancer metastasis. The levels of Cytokeratin 13 were able to predict bone metastasis and overall survival rate of the patient.