CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is composed of a single Ig V like extracellular domain, a transmembrane domain and an intracellular domain and belongs to immunoglobulin (Ig) gene superfamily. It is structurally homologous to CD28 and is expressed on CD4+ cytotoxic T cells. CTLA-4 is a strong inhibitor of T-cell activation and is functions in T-cell apoptosis. CTLA-4 is also found intracellularly in regulatory T-cells and is important for their function.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: F-8
Source: Mouse
Tissue Type: Heart Tissue