CSF1R (Colony stimulating factor 1 receptor), also known as?M-CSFR (macrophage colony-stimulating factor receptor) and?CD115, is a?receptor?for CSF1 (colony stimulating factor 1), a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Activated CSF1R promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes which can further influence the development of tumors. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy and overexpression of CSF1R has been confirmed in various malignant tumors. Blockade of CSF1R enables the therapeutic targeting of tumor-associated macrophages (TAM) in cancer patients. Various CSF-1R inhibitors, mAbs (e.g. emactuzumab), and tyrosine kinase inhibitors are currently evaluated in early clinical trials.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual