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Anti-CSF-1R

SKU: AN914GPE Categories: , , ,
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Product Description

CSF1R (Colony stimulating factor 1 receptor), also known as?M-CSFR (macrophage colony-stimulating factor receptor) and?CD115, is a?receptor?for CSF1 (colony stimulating factor 1), a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Activated CSF1R promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes which can further influence the development of tumors. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy and overexpression of CSF1R has been confirmed in various malignant tumors. Blockade of CSF1R enables the therapeutic targeting of tumor-associated macrophages (TAM) in cancer patients. Various CSF-1R inhibitors, mAbs (e.g. emactuzumab), and tyrosine kinase inhibitors are currently evaluated in early clinical trials.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

SP211

Source

Rabbit

Tissue Type/Cancer Type

Tonsil

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual