Datasheet SDS

The enzyme cyclooxygenase (COX), also known as prostaglandin H synthase or prostaglandin endoperoxide synthase, consists of two isoforms, COX-1 and COX-2. Both isoforms are associated with inner membranous compartments and represent key enzymes in the conversion of arachidonic acid to prostaglandin. COX-1 is constitutively expressed in most cell types and is involved in the homeostasis of various physiological functions, while COX-2 is considered to be a mitogen-inducible form, associated with biologic events such as injury, inflammation, and proliferation. COX-2 plays an important role in carcinogenesis of various human cancers, including colorectal cancer and cervical cancer. COX-2 has been studied as a key rate-limiting enzyme for prostanoid biosynthesis.