CDX2 is an intestine-specific transcription factor, it is a member of the caudal-related homeobox family that regulates both proliferation and differentiation in intestinal epithelial cells. It plays an important role in triggering cells towards the phenotype of differentiated villus enterocytes as well as in the maintenance of the phenotype. Clone CDX2-88 reacts with a conserved epitope of the 40kD CDX2 protein localized in the nucleus. It exclusively marks nuclei of colonic epithelial cells and colorectal cancers on formalin-fixed, paraffin-embedded tissue sections
Intended Use: IVD
Antibody Type: Monoclonal
Clone: CDX2-88
Source: Mouse
Tissue Type/Cancer Type: Colon