CDK4 (cyclin-dependent kinase 4) is a 34 kDa member of the serine/threonine protein kinase family. CDK4 is phosphorylated, forms a complex with cyclin D1, 2 or 3, and phosphorylates pRb/retinoblastoma protein leading to inactivativation of pRb and cells initiate DNA synthesis. Mutations in CDK4 gene are found to be associated with tumorigenesis of a variety of cancers. CDK4 expression is seen in a variety of normal cells and tissues as well as in cancer cells. CDK4 is overexpressed in human tumors like malignant melanoma, glioma, sarcoma and carcinomas of the breast, urothelial, colon, lung, ovary and oral cavity.
| Intended Use | IVD |
|---|---|
| Pack | 6 mL (RTU), 10 mL (RTU), 1 mL(Conc.), 0.5 mL (Conc.), 200 tests – Xmatrx Elite, 50 tests – Xmatrx Elite, 5 slides – Xmatrx, 5 slides – Manual |
