CDK2 (Cyclin-dependent kinase 2), also known as cell division protein kinase 2, is a serine/threonine protein kinases?that participate in cell cycle regulation and is especially critical during the G1 to S phase transition. CDK2 phosphorylates a large number of proteins involved in cell cycle progression (e.g. p27KIP1 and RB), DNA replication (e.g., replication factors A and C), histone synthesis (e.g., NPAT), centrosome duplication (e.g., nucleophosmin), among other processes. CDK2 is known to phosphorylate Akt on Ser477 and Thr479 promoting its activation at a specific stage during cell cycle progression . Recently, it has become clear that deregulation of CDK2 also occurs frequently in certain types of cancer. Increased CDK2 activity was shown to decreases risk in colon cancer, but elevates poor outcome in specific tumors, including low grade glioma, kidney, thyroid, adrenocortical and prostate cancer.
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0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual