CDK1 (Cyclin-dependent kinase 1), also known as CDC2 (cell division cycle protein 2 homolog)?is a highly conserved?protein?that functions as a serine/threonine?kinase, and is a key player in?cell cycle?regulation and the only CDK that can initiate the onset of mitosis. At the onset of mitosis activation of CDK1 occurs rapidly. Subsequently, CDK1 forms complexes with its?cyclin?partners (Cyclin A2 and Cyclin B1) and phosphorylates?a variety of target substrates (over 75 have been identified in budding yeast), leading to nuclear envelope breakdown, chromosome condensation, mitotic spindle assembly and cell cycle progression. Derangement of p53 signaling or of DNA damage checkpoints indi?rectly leads to the deregulation of CDK1, and high cyclin B1 expression is generally associated with a more aggressive cancer phenotype. Diseases associated with CDK1 include Breast Cancer and Hepatocellular Carcinoma.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual