CD82, also known as metastasis suppressor Kangai-1 (KAI1), is a member of the tetraspanin protein family and is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion and migration to apoptosis and cell-morphology alterations. In tumors, the expression of CD82 has been shown to be downregulated in tumor progression. CD82 can be activated by p53 through a consensus binding sequence in the promoter. Loss of p53 function, which is commonly observed in many types of cancers, may lead to the downregulation of the CD82 gene. The correlation between lower or no expression of CD82 and poor tumor prognosis is observed in many types of tumors, including prostate, breast, colon, stomach, bladder, lung, liver, pancreas, and ovary tumors
Intended Use: IVD
Antibody Type: Monoclonal
Clone: EP160
Source: Rabbit
Tissue Type/Cancer Type: Adeno Ca