The CD8 antigen also known as T8 or Leu2 or Lyt2 or T cell coreceptor is made of ? and ? chain linked by disulphide bond to form ?/? heterdimer of molecular weight 32kD. CD8 is a type 1 member protein in the immunoglobulin supergene family and also plays a role in the process of T-cell mediated killing. CD8 is a stage marker of T cell development in the thymus, and is expressed on ?mature peripheral T cells, most cytotoxic T cells, CD4/CD8+ thymocytes, NK cells and cortical thymocytes. CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 ? chain (but not ? chain)
Intended Use: IVD
Antibody Type: Monoclonal
Clone: SP16
Source: Rabbit
Tissue Type/Cancer Type: Tonsil