CD73 or NT5E (ecto-5?-nucleotidase) is a GPI-anchored enzyme that generates extracellular adenosine, a potent immunosuppressive metabolite in the tumor microenvironment. CD73?adenosinergic pathway contributes to tumor immune escape in animal mouse models of cancerand was also shown to suppress antitumor T cells in human ovarian cancer. Monoclonal antibody treatment targeting CD73 has been shown to delay ovarian tumor growth in mice and to rescue human T-cell functions when co-cultured with CD73-expressing human ovarian cancer cells. CD73 over expression was demonstrated in various cancer including breast cancer, colon cancer, glioma, leukemia, melanoma, ovarian cancer, pancreatic cancer, prostate cancer and thyroid cancer.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: 1D7
Source: Mouse
Tissue Type/Cancer Type: Tonsil