The CD68 is a transmembrane protein of 87-115 kDa with heavy glycosylation, it is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendriticcells. CD68 acts as a marker monocyte/macrophage lineage cells. CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. This antibody is capable of staining monocytes, Kupffer cells, osteoclasts, granulocytes and their precursors; Lymphomas are negative or show a few granules. This antibody may be useful for the identification of Myelomonocytic and Histiocytic Tumors. CD68 may help to distinguish Malignant Fibrous Histiocytoma from other Pleomorphic Sarcomas. However, since CD68 detects a formalin-resistant epitope that may be associated with lysosomal granules, other lysosome-rich cells may also produce positive results
Intended Use: IVD
Antibody Type: Monoclonal
Clone: CD68/G2
Source: Mouse
Tissue Type/Cancer Type: Histiocytoma