CD56, also known as a neural cell adhesion molecule, is a homophilic binding glycoprotein expressed on the cell surface of neural, glial and skeletal muscle cells. CD56 is a phenotypical marker for natural killer cells and many other immune cells, including alpha-beta T cells, gamma delta T cells, dendritic cells and monocytes. Depending on the way the protein is spliced, the functions could vary vastly. In general, Twenty-seven forms of NCAM were found by analysis of individual NCAM transcripts. The expression of alternatively spliced forms of NCAM is developmentally regulated and therefore suggests a role for NCAM in development. Alpha 2, 8-linked polysialic acid modification of NCAM plays an important role in neural development and synaptic plasticity. In Immunohistochemistry, CD56 antibodies can be used to distinguish many tumors such as myeloma, Wilm?s Tumor, neuroblastoma, Ewing?s Sarcoma and many others.
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | 128A8 |
| Source | Mouse |
| Tissue Type/Cancer Type | Cerebellum |
| Pack | 0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
