CD47, also designated as integrin-associated protein (IAP), is a 50kDa five-pass transmembrane protein that plays a role in the regulation of cation fluxes across cell membranes. It also binds with the C-terminal cell binding domain of thrombospondin (SIRPa) and leads to inhibition of macrophage phagocytosis towards CD47-expressing cells. In this way, CD47 serves as “don’t eat me” signal or a marker of “self”, functioning as an
innate immune checkpoint. CD47 is expressed on normal, healthy hematopoietic stem cells (HSC), brain, mesenchymal cells, epithelial cells, endothelial cells, fibroblasts and is overexpressed in many types of cancer.
|Tissue Type/Cancer Type||
Placenta, Brain, prostate carcinoma and ovarian carcinoma tissue
1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual