The CD22 antigen also known as BL-CAM is a single chain type I transmembrane molecule which contains seven Ig-like domains and molecular weight of 130 to 140kD. In humans, IgM(+) IgD(+) B cells express cell-surface CD22. CD22 molecule is suggested as a component of the B-cell activation complex and as an adhesion molecule. In B-cell malignancies, CD22 marker varies from 60% to 80% depending on the histological type and on the assays used. CD22 antigen is weakly expressed in myeloid leukemias and non-T cell acute lymphoblastic leukemias and is strongly expressed in hairy cell leukaemias. It is absent on peripheral blood T cells, T cell leukemias, granulocytes and monocytes
Intended Use: IVD
Antibody Type: Monoclonal
Clone: FPC1
Source: Mouse
Tissue Type/Cancer Type: Tonsil