CD-22, a B-cell transmembrane glycoprotein, is part of the immunoglobulin superfamily. The Ig domain of the CD-22 molecule binds to the Sialic acid particularly. It has been shown that CD-22 is a negative regulator of the BCR signal and therefore has a role in suppression of the immune response. CD-22 has also been linked to having a role in TLR signaling and B- cell survival. Defects in CD-22 has been linked to poor regulation of BCR and thus causing hyper responsive B-cells that lead to autoimmune diseases like Systemic Lupus erythematoses.
|Tissue Type/Cancer Type||
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual