CD-22, a B-cell transmembrane glycoprotein, is part of the immunoglobulin superfamily. The Ig domain of the CD-22 molecule binds to the Sialic acid particularly. It has been shown that CD-22 is a negative regulator of the BCR signal and therefore has a role in suppression of the immune response. CD-22 has also been linked to having a role in TLR signaling and B- cell survival. Defects in CD-22 has been linked to poor regulation of BCR and thus causing hyper responsive B-cells that lead to autoimmune diseases like Systemic Lupus erythematoses.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: BLCAM/1795
Source: Mouse
Tissue Type/Cancer Type: Spleen

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