CD21 is a type 2 single-pass transmembrane protein that acts as a complementary receptor for the Epstein-Barr virus and C3d molecule. CD21 is helpful in the recognition of follicular dendritic cell matrix found in tonsillar tissue and normal lymph node. Anti CD21 Antibody also identifies follicular dendritic cell sarcomas. Anti-CD21 is important in differentiating marginal zone lymphoma with follicular involvement from follicular lymphoma with marginal zone differentiation. CD21 plays a role in separating among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers. The antigen is absent on T-lymphocytes, monocytes, and granulocytes.
|Tissue Type/Cancer Type|
0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual