DatasheetSDS

CD163 is a member of the SRCR family class B and is expressed in most subpopulations of mature tissue macrophages. The SRCR superfamily is a family of structurally related transmembrane glycoproteins. The characteristic building block of the extracellular domain of these molecules is the SRCR domain, which is an ancient and highly conserved domain of approximately 110 residues. The best characterized function of CD163 is related to the binding of the Hemoglobin: Haptoglobin complexes. There is evidence that CD163 also plays a role in host defense. It has been shown that CD163 can interact and bind with gram-positive and gram-negative bacteria, functioning like a macrophage receptor. It has also been suggested that the soluble form of CD163 plays role in resolution of inflammation, due to their prevalence in inflamed tissue.