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Anti-CD16

SKU: AM437GP Categories: , , ,
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Product Description

CD16 antigen is also known as Fc gamma receptor III and has a molecular weight of 50 to 70kD. It is a low affinity Fc receptor for complexed IgG-Fc gamma RIII, expressed on natural killer (NK) cells, granulocytes, activated macrophages and a subset of T cells expressing alpha-beta or gamma-delta T cell antigen receptors. The CD16 antigen exists both as a polypeptide-anchored form (FCgammaRIIIA or CD16A) on NK cells and monocytes/ macrophages and as a glycosylphosphatidyl-inositol (GPI)-anchored form (FcgammaRIIIB or CD16B) on neutrophils. Antibody-dependent cytotoxicity of NK cells is triggered by the engagement of CD16 with the Fc portion of IgG immunoglobulins bound to target cell-associated antigens. This antibody may be useful in the study of NK cell activity in autoimmune, neoplastic and infectious diseases

Intended Use

IVD

Antibody Type

Monoclonal

Clone

2H7

Source

Mouse

Tissue Type/Cancer Type

Lymph Node

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual