Anti-CD147, Clone BSG/963


The human CD147 molecule is a transmembrane glycoprotein, also known as basigin, OK blood group, collagenase stimulatory factor, M6 antigen, neurothelin or extracellular matrix metalloproteinase inducer (EMMPRIN). It is thought to bind an unidentified ligand on fibroblasts which stimulates the production of collagenase and other extracellular matrix metalloproteinases enhancing tumor cell invasion and metastasis. The CD147 molecule is reported to have a broad expression pattern in both hematopoietic and nonhematopoietic tissues and is upregulated upon cell activation. These enzymes are important factors in cancer invasion and metastasis. CD147 expression is reported to be dependent upon the state of differentiation. CD147 overexpression has been reported in neoplasms of the bladder, liver and lung.
Intended Use: IVD