Anti-CD123 (IL3RA), Clone IL3RA/1531


Interleukin 3 receptor alpha (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GMCSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor ? chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chains (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y.
Intended Use: IVD