CD11b are cell adhesion molecules that acts as receptors for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. The protein CD11b is involved in different cell adhesion-related interactions of monocytes, macrophages, natural killer (NK) cells, and granulocytes. The Integrins are hetero-dimeric proteins that are made up of an α chain and β chain, and are part of a heterodimer that consists of CD11b and CD18. CD11b is a common microglial marker in tissues derived from the nervous system. It may play a role in mast cell development. They are also required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
Intended Use: IVD
Antibody Type: Monoclonal
Clone: ITGAM/3340
Source: Mouse
Tissue Type/Cancer Type: Tonsil Tissue