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Cathepsin K also designated as CTSK, CTSO, CTSO2, is a lysosomal cysteine protease belongs to the papain cysteine protease family. It is an important protease involved in bone remodeling and resorption by degrading type I collagen, osteopontin, and other bone matrix proteins. Cathepsin K expression is observed in bone, cartilage and skeletal muscle. Its expression is also seen in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness.