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Anti-Cathepsin D

SKU: AM961GP Categories: , , ,
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Product Description

Cathepsin D is a soluble aspartic endopeptidase found in the lysosomes of most mammalian cells. Cathepsin D is activated by proteolytic cleavage of the synthesized inactive zymogen (preproCathepsin D), which is composed of an N-terminal signal peptide, a propeptide, and a catalytic domain. Cathepsin D plays a role in general protein degradation and turnover within the lysosomal compartment, as an important signaling and regulator molecule. Overexpression of Cathepsin D spans across varieties of cancers and is often correlated with poor prognosis. Cathepsin D?s role in pathology is attributed to apoptosis and neurodegeneration.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

CTSD/3082

Source

Mouse

Tissue Type/Cancer Type

Lung

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual