Caspase-3 (also designated as SCA-1, Apopain, CPP-32, Yama,) is a 32 kDa aspartate-specific cysteine protease that belongs to the ICE subfamily of Caspase family. It is a crucial executioner of apoptosis by proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. During apoptotic cascade, active caspase-3 is responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). It also cleaves and activates sterol regulatory element binding proteins (SREBPs), caspase-6, -7 and -9. High expression of caspase-3 is observed in lung, kidney, liver, heart, spleen, and cells of the immune system.
|Tissue Type/Cancer Type||
Urinary bladder, Duodenum, stomach tissues
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