Caspase-3 (also designated as SCA-1, Apopain, CPP-32, Yama,) is a 32 kDa aspartate-specific cysteine protease that belongs to the ICE subfamily of Caspase family. It is a crucial executioner of apoptosis by proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. During apoptotic cascade, active caspase-3 is responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). It also cleaves and activates sterol regulatory element binding proteins (SREBPs), caspase-6, -7 and -9. High expression of caspase-3 is observed in lung, kidney, liver, heart, spleen, and cells of the immune system.
| Intended Use | IVD |
|---|---|
| Antibody Type | Cytoplasm |
| Clone | B-4 |
| Source | Mouse |
| Tissue Type/Cancer Type | Urinary bladder, Duodenum, stomach tissues |
| Pack | 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 6 mL – Manual – RTU, 10 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP, 160 Tests – Automation – Xmatrx |
