DatasheetSDS

Carbonic anhydrase IX (CA-IX) is a cell surface transmembrane protein, belongs to the monomeric alpha class of zinc metalloenzymes called as Carbonic anhydrases. These enzymes catalyze the rapid hydration of carbon dioxide and water into carbonic acid, bicarbonate ions and protons. CAIX also participates in cellular pH regulation across the membrane by cooperating with sodium bicarbonate co-transporters (NBC), sodium/hydrogen exchanger (NHE) and lactate and proton exporting monocarboxylic acid transporters (MCT). It is predominantly expressed in the all clear-cell renal cell carcinomas, common epithelial tumors such as carcinomas of the esophagus, lung, colon, kidney, cervix, non-small cell lung carcinoma, gastrointestinal tract and gallbladder but is not detected in most of the normal tissues. Hence it is known to be one of tumor-associated carbonic anhydrase isoenzyme.