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C-myc (also known as myc) is a transcription factor belongs to the Myc family together with l-Myc and n-Myc. It has a basic helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. C-myc acts as a proto-oncogene and regulates the cellular changes including increased production of nucleic acids, proteins and lipids that are required for rapid cellular proliferation. C-myc is ubiquitously expressed in almost all cell types during embryogenesis and is upregulated in many cancer types especially in aggressive, poorly differentiated tumors. Amplification of the c-Myc gene was first discovered in patients with Burkitt lymphoma and is found in several types of human tumors including lung, breast and colon carcinomas.