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Anti-c-Kit / CD117

SKU: AN818GPE Categories: , , ,
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Product Description

CD117 is a proto-oncogene, meaning that overexpression or mutations of this protein can lead to cancer. Seminomas, a subtype of testicular germ cell tumors. Member of the Tyrosine Kinase Receptor (TKRs) and highly homologous to receptor PDF and CSF-1. Activation of c-Kit tyrosine kinase by SCF (Stem Cell factor) leads to autophosphorylation and association of c-Kit with substrate PI3K. CD117 is a marker for Mast cell and gastrointerstinal stroma tumor.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

EP10

Source

Rabbit

Tissue Type/Cancer Type

Stomach

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 200 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual