Her-2/neu (c-erb-B2) gene product is a 185 kDa tyrosine kinase transmembrane glycoprotein. Her-2/neu belongs to erb gene family. Her-2/neu has been linked to prognosis and response to therapy with the anti-HER-2-humanized monoclonal antibody. The antibody CB11 is directed against the internal domain of this oncoprotein. Approximately 20-30% cases of breast cancer show an amplification and/or overexpression of Her-2 in tumor cells. Since there is an availability of the target therapy to Her-2 Neu positive tumors, the lab testing of Her-2/neu in breast carcinoma becomes very important in patient care
| Intended Use | IVD |
|---|---|
| Antibody Type | Monoclonal |
| Clone | CB11 |
| Source | Mouse |
| Tissue Type/Cancer Type | Breast Ca |
| Pack | 6 mL – Manual – RTU, 100 Tests – Automation – i6000, 1 mL – Manual – Concentrate, 0.5 mL – Manual – Concentrate, 50 Tests – Automation – Xmatrx, 50 tests – NanoVIP®, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual |
