Anti-BOB-1, Clone TG14


B cell specific Octamer Binding protein-1 is a Coactivator of OCT-2. It appears to mediate antigen-dependent germinal center formation. BOB1 is recommended for use as part of a panel of antibodies to aid in the differentiation of malignancies of B cell origin. BOB.1 expression in a variety of established B-cell lines, represents different stages of B-cell development has shown a Bcell-specific expression pattern. LP cells in nodular lymphocyte that are predominant Hodgkin lymphoma their germinal centerderived are consistently immune positive for BOB.1. Some cases of classical Hodgkin lymphoma show BOB.1 immune-reactivity with the Hodgkin and Reed-Sternberg cells. Expression of BOB.1 was said to be seen in follicular center cell lymphoma, diffuse large B-cell lymphoma and some acute myeloid leukemia. B-CLL, marginal zone lymphoma, and mantle cell lymphoma may show weak to moderate staining
Intended Use: IVD