Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Enhanced expression of Lewis A antigen has been found in malignant transformation of gastric tissues. A panel of antibodies to Lewis antigens, including Lewis A, Lewis B and sialylated Lewis A, is useful in the immunopathological analysis of gastric cancers.
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