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Anti-Beta-Catenin
SKU: AN778GP Categories: , ,

Beta-Catenin is a regulatory protein of Wnt pathway with key roles in cell adhesion and signal transduction, development, cellular proliferation, and differentiation. Mutations of Beta-Catenin gene are commonly found in a variety of cancers: in primary hepatocellular carcinoma, colorectal cancer, ovarial carcinoma, breast cancer, lung cancer and glioblastoma. Mutations occuring in the Beta-Catenin gene CTNNB1 leads to stabilization of Beta-Catenin in the cytoplasm and translocation to the nucleus have been implicated in various forms of tumor including familial adenomatous polyposis, fibromatosis, solitary fibrous tumors and endometrial carcinoma. A nuclear accumulation of Beta-Catenin in fibromatosis (desmoid tumor) in various locations including breast and mesentery is useful in the differentiation of this tumor from other fibroblast like lesions

Intended Use

IVD

Antibody Type

Monoclonal

Clone

EP35

Source

Rabbit

Tissue Type/Cancer Type

Breast

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual