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Anti-BCL-x
SKU: AN819GP Categories: , ,

Bcl-X, or bcl-2-like 1 protein, a member of the bcl-2 protein family, inhibits cell death or apoptosis and functions as a regulator of apoptosis. Bcl-X has two isoforms: Bcl-XL (Long), a 241-amino acid protein; and Bcl-XS (Short), a 178-amino acid protein lacking a 63-amino acid domain that is well conserved among members of the bcl-2 family. Bcl-X is typically present in the cytosol in association with the mitochondrial membrane.Bcl-x is expressed in many types of cell including lymphocytes, neuronal cells, and epithelial cells. In tumors, a high level of Bcl-x has been found in Reed Sternberg cells in Hodgkin?s disease. Overexpression of Bcl-x has been observed in primary central nervous system lymphomas that occur in immunosuppressed patients. In prostate cancer, Bcl-x expression is increased during tumor progression. Overexpression of Bcl-x in colon cancer has been linked to a poor prognosis.

Intended Use

IVD

Antibody Type

Monoclonal

Clone

EP94

Source

Rabbit

Tissue Type/Cancer Type

Tonsil

Pack

0.5 mL – Manual – Concentrate, 1 mL – Manual – Concentrate, 6 mL – Manual – RTU, 50 Tests – Automation – Xmatrx, 100 Tests – Automation – i6000, 160 Tests – Automation – Xmatrx, 5 slides – Xmatrx, 5 slides – Manual